diff --git a/include/wx/chkconf.h b/include/wx/chkconf.h
index 4b069bebc8..b1c741e43d 100644
--- a/include/wx/chkconf.h
+++ b/include/wx/chkconf.h
@@ -1451,7 +1451,7 @@
  */
 #if wxUSE_GUI
 
-#if wxUSE_ACCESSIBILITY && !defined(__WXMSW__) && !defined(__GCCXML__)
+#if wxUSE_ACCESSIBILITY && !defined(__WXMSW__)
 #   ifdef wxABORT_ON_CONFIG_ERROR
 #       error "wxUSE_ACCESSIBILITY is currently only supported under wxMSW"
 #   else
diff --git a/include/wx/platform.h b/include/wx/platform.h
index 50476b9e5f..cdd8b9ce48 100644
--- a/include/wx/platform.h
+++ b/include/wx/platform.h
@@ -153,15 +153,6 @@
  */
 #include "wx/setup.h"
 
-#ifdef __GCCXML__
-    /*
-        we're using gccxml to create an XML representation of the entire
-        wxWidgets interface; use a special setup_gccxml.h file to fix some
-        of the stuff #defined by the real setup.h
-    */
-    #include "wx/setup_gccxml.h"
-#endif
-
 /*
    Convenience for any optional classes that use the wxAnyButton base class.
  */
diff --git a/include/wx/setup_gccxml.h b/include/wx/setup_gccxml.h
deleted file mode 100644
index baa6cbd96f..0000000000
--- a/include/wx/setup_gccxml.h
+++ /dev/null
@@ -1,23 +0,0 @@
-///////////////////////////////////////////////////////////////////////////////
-// Name:        wx/setup_gccxml.h
-// Purpose:     setup.h settings for gccxml (see utils/ifacecheck)
-// Author:      Francesco Montorsi
-// Modified by:
-// RCS-ID:      $Id$
-// Copyright:   (c) Francesco Montorsi
-// Licence:     wxWindows licence
-///////////////////////////////////////////////////////////////////////////////
-
-/*
-    This file is included by wx/platform.h when gccxml is detected.
-
-    Here we fix some of the things declared in the real setup.h which gccxml doesn't
-    like.
-*/
-
-
-// gccxml 0.9.0 doesn't like the fcntl2.h which is part of GNU C library
-// (at least it doesn't on x86_64 systems!)
-#define _FCNTL_H
-int open (const char *__path, int __oflag, ...);
-