diff --git a/wxPython/setup.py b/wxPython/setup.py
index 2e161a8ff9..0711a24bb7 100755
--- a/wxPython/setup.py
+++ b/wxPython/setup.py
@@ -16,7 +16,7 @@ from distutils.command.install_data import install_data
 VER_MAJOR        = 2      # The first three must match wxWindows
 VER_MINOR        = 4
 VER_RELEASE      = 2
-VER_SUBREL       = 0       # wxPython release num for x.y.z release of wxWindows
+VER_SUBREL       = 1       # wxPython release num for x.y.z release of wxWindows
 VER_FLAGS        = "p"     # release flags, such as prerelease num, unicode, etc.
 
 DESCRIPTION      = "Cross platform GUI toolkit for Python"
diff --git a/wxPython/src/__version__.py b/wxPython/src/__version__.py
index 1feb20bae8..6199dc3714 100644
--- a/wxPython/src/__version__.py
+++ b/wxPython/src/__version__.py
@@ -1,10 +1,10 @@
 # This file was generated by setup.py...
 
-wxVERSION_STRING  = '2.4.1.3p'
+wxVERSION_STRING  = '2.4.2.1p'
 wxMAJOR_VERSION   = 2
 wxMINOR_VERSION   = 4
-wxRELEASE_VERSION = 1
-wxSUBREL_VERSION  = 3
+wxRELEASE_VERSION = 2
+wxSUBREL_VERSION  = 1
 
 wxVERSION = (wxMAJOR_VERSION, wxMINOR_VERSION, wxRELEASE_VERSION,
              wxSUBREL_VERSION, 'p')