diff --git a/include/wx/setup.h b/include/wx/setup.h
index f0afb89655..8f4372749a 100644
--- a/include/wx/setup.h
+++ b/include/wx/setup.h
@@ -15,6 +15,9 @@
 #error No __WXxxx__ define set! Please define one of __WXGTK__,__WXMSW__,__WXMOTIF__,__WXMAC__,__WXQT__,__WXPM__,__WXSTUBS__
 #endif
 
+#ifdef __VMS
+#include "[--]setup.h"
+#elif
 #if defined(__WXMSW__)
 #include "wx/msw/setup.h"
 #elif defined(__WXMAC__)
@@ -30,6 +33,7 @@
 #elif defined(__WXGTK__)
 #include "wx/gtk/setup.h"
 #endif
+#endif
 
 /*
  * Compatibility defines: note that, in general, there is a a reason for not