diff --git a/build/cmake/setup.h.in b/build/cmake/setup.h.in
index db6e294e51..910ab84305 100644
--- a/build/cmake/setup.h.in
+++ b/build/cmake/setup.h.in
@@ -691,11 +691,7 @@
     #cmakedefine01 wxUSE_GRAPHICS_DIRECT2D
 #endif
 
-#if defined(_MSC_VER) || defined(__MINGW64_VERSION_MAJOR)
-    #cmakedefine01 wxUSE_WEBREQUEST_WINHTTP
-#else
-    #cmakedefine01 wxUSE_WEBREQUEST_WINHTTP
-#endif
+#cmakedefine01 wxUSE_WEBREQUEST_WINHTTP
 
 
 #cmakedefine01 wxUSE_OLE
diff --git a/include/wx/gtk/setup.h b/include/wx/gtk/setup.h
index 77b1827e0f..6695285e4a 100644
--- a/include/wx/gtk/setup.h
+++ b/include/wx/gtk/setup.h
@@ -1650,11 +1650,7 @@
 //
 // Recommended setting: 1, can be set to 0 if wxUSE_WEBREQUEST_CURL==1,
 // otherwise wxWebRequest won't be available at all.
-#if defined(_MSC_VER) || defined(__MINGW64_VERSION_MAJOR)
-    #define wxUSE_WEBREQUEST_WINHTTP 1
-#else
-    #define wxUSE_WEBREQUEST_WINHTTP 0
-#endif
+#define wxUSE_WEBREQUEST_WINHTTP 1
 
 // ----------------------------------------------------------------------------
 // Windows-only settings
diff --git a/include/wx/msw/chkconf.h b/include/wx/msw/chkconf.h
index 87ac46f30d..f9a3ac8aba 100644
--- a/include/wx/msw/chkconf.h
+++ b/include/wx/msw/chkconf.h
@@ -235,6 +235,11 @@
 #   define wxUSE_ACTIVITYINDICATOR 0
 #endif /* !wxUSE_ACTIVITYINDICATOR && !_MSC_VER */
 
+/* MinGW-w64 (32 and 64 bit) has winhttp.h available, legacy MinGW does not. */
+#if (!defined(_MSC_VER) && !defined(__MINGW64_VERSION_MAJOR))
+    #undef wxUSE_WEBREQUEST_WINHTTP
+    #define wxUSE_WEBREQUEST_WINHTTP 0
+#endif
 /*
     Similarly, turn off wxUSE_WEBREQUEST if we can't enable it because we don't
     have any of its backends to allow the library to compile with the default
diff --git a/include/wx/msw/setup.h b/include/wx/msw/setup.h
index 262f732c94..7b4494ce10 100644
--- a/include/wx/msw/setup.h
+++ b/include/wx/msw/setup.h
@@ -1650,11 +1650,7 @@
 //
 // Recommended setting: 1, can be set to 0 if wxUSE_WEBREQUEST_CURL==1,
 // otherwise wxWebRequest won't be available at all.
-#if defined(_MSC_VER) || defined(__MINGW64_VERSION_MAJOR)
-    #define wxUSE_WEBREQUEST_WINHTTP 1
-#else
-    #define wxUSE_WEBREQUEST_WINHTTP 0
-#endif
+#define wxUSE_WEBREQUEST_WINHTTP 1
 
 // ----------------------------------------------------------------------------
 // Windows-only settings
diff --git a/include/wx/msw/setup_inc.h b/include/wx/msw/setup_inc.h
index 4957536e92..480b7a9344 100644
--- a/include/wx/msw/setup_inc.h
+++ b/include/wx/msw/setup_inc.h
@@ -44,11 +44,7 @@
 //
 // Recommended setting: 1, can be set to 0 if wxUSE_WEBREQUEST_CURL==1,
 // otherwise wxWebRequest won't be available at all.
-#if defined(_MSC_VER) || defined(__MINGW64_VERSION_MAJOR)
-    #define wxUSE_WEBREQUEST_WINHTTP 1
-#else
-    #define wxUSE_WEBREQUEST_WINHTTP 0
-#endif
+#define wxUSE_WEBREQUEST_WINHTTP 1
 
 // ----------------------------------------------------------------------------
 // Windows-only settings
diff --git a/setup.h.in b/setup.h.in
index 711f4dc682..895b8f2b57 100644
--- a/setup.h.in
+++ b/setup.h.in
@@ -691,11 +691,7 @@
     #define wxUSE_GRAPHICS_DIRECT2D 0
 #endif
 
-#if defined(_MSC_VER) || defined(__MINGW64_VERSION_MAJOR)
-    #define wxUSE_WEBREQUEST_WINHTTP 0
-#else
-    #define wxUSE_WEBREQUEST_WINHTTP 0
-#endif
+#define wxUSE_WEBREQUEST_WINHTTP 0
 
 
 #define wxUSE_OLE           0