diff --git a/setup.h.in b/setup.h.in
index f2ab51039f..b889f0d9a1 100644
--- a/setup.h.in
+++ b/setup.h.in
@@ -897,6 +897,12 @@
 /* Define if you have support for large (64 bit size) files */
 #undef HAVE_LARGEFILE_SUPPORT
 
+/* Required by HAVE_LARGEFILE_SUPPORT on some systems */
+#undef _FILE_OFFSET_BITS
+
+/* Ditto */
+#undef _LARGE_FILES
+
 /* Define if you have localtime() */
 #undef HAVE_LOCALTIME