diff --git a/configure.in b/configure.in
index 459c4ac208..b01862c8a0 100644
--- a/configure.in
+++ b/configure.in
@@ -5079,7 +5079,9 @@ if test "$wxUSE_DEBUG_FLAG" = "yes" ; then
     WXCONFIG_CPPFLAGS="$WXCONFIG_CPPFLAGS -D__WXDEBUG__"
 else
     if test "$wxUSE_GTK" = 1 ; then
-        CPPFLAGS="-DGTK_NO_CHECK_CASTS $CPPFLAGS"
+        if test "x$wxGTK_VERSION" = "x1" ; then
+            CPPFLAGS="-DGTK_NO_CHECK_CASTS $CPPFLAGS"
+        fi
     fi
 fi