diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 6ad5ef60e9..8052a6427a 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -8,6 +8,7 @@ on:
     paths-ignore:
       - '.github/workflows/ci_mac_selfhosted.yml'
       - '.github/workflows/ci_cmake.yml'
+      - '.github/workflows/ci_msw.yml'
       - '.github/workflows/ci_msw_cross.yml'
       - 'build/tools/appveyor*.bat'
       - 'distrib/**'
@@ -26,6 +27,7 @@ on:
     paths-ignore:
       - '.github/workflows/ci_mac_selfhosted.yml'
       - '.github/workflows/ci_cmake.yml'
+      - '.github/workflows/ci_msw.yml'
       - '.github/workflows/ci_msw_cross.yml'
       - 'build/tools/appveyor*.bat'
       - 'distrib/**'
diff --git a/.github/workflows/ci_cmake.yml b/.github/workflows/ci_cmake.yml
index 2a5e599db7..4309ec34b5 100644
--- a/.github/workflows/ci_cmake.yml
+++ b/.github/workflows/ci_cmake.yml
@@ -8,6 +8,7 @@ on:
     paths-ignore:
       - '.github/workflows/ci.yml'
       - '.github/workflows/ci_mac_selfhosted.yml'
+      - '.github/workflows/ci_msw.yml'
       - '.github/workflows/ci_msw_cross.yml'
       - 'build/tools/appveyor*.bat'
       - 'distrib/**'
@@ -26,6 +27,7 @@ on:
     paths-ignore:
       - '.github/workflows/ci.yml'
       - '.github/workflows/ci_mac_selfhosted.yml'
+      - '.github/workflows/ci_msw.yml'
       - '.github/workflows/ci_msw_cross.yml'
       - 'build/tools/appveyor*.bat'
       - 'distrib/**'
diff --git a/.github/workflows/ci_mac_selfhosted.yml b/.github/workflows/ci_mac_selfhosted.yml
index 96dcc3ee54..f62e9f4c0f 100644
--- a/.github/workflows/ci_mac_selfhosted.yml
+++ b/.github/workflows/ci_mac_selfhosted.yml
@@ -7,6 +7,7 @@ on:
     paths-ignore:
     - '.github/workflows/ci.yml'
     - '.github/workflows/ci_cmake.yml'
+    - '.github/workflows/ci_msw.yml'
     - '.github/workflows/ci_msw_cross.yml'
     - 'build/tools/appveyor*.bat'
     - 'distrib/**'
@@ -34,6 +35,7 @@ on:
     paths-ignore:
     - '.github/workflows/ci.yml'
     - '.github/workflows/ci_cmake.yml'
+    - '.github/workflows/ci_msw.yml'
     - '.github/workflows/ci_msw_cross.yml'
     - 'build/tools/appveyor*.bat'
     - 'distrib/**'
diff --git a/.github/workflows/ci_msw.yml b/.github/workflows/ci_msw.yml
new file mode 100644
index 0000000000..e0ed0653bb
--- /dev/null
+++ b/.github/workflows/ci_msw.yml
@@ -0,0 +1,90 @@
+# CI workflow building wxMSW under Windows.
+name: MSW builds
+
+on:
+  push:
+    branches:
+      - master
+    paths-ignore:
+      - '.github/workflows/ci.yml'
+      - '.github/workflows/ci_cmake.yml'
+      - '.github/workflows/ci_mac_selfhosted.yml'
+      - '.github/workflows/ci_msw_cross.yml'
+      - 'build/tools/appveyor*.bat'
+      - 'distrib/**'
+      - 'docs/**'
+      - 'interface/**'
+      - 'include/wx/gtk/**'
+      - 'include/wx/osx/**'
+      - 'locale/**'
+      - 'src/gtk/**'
+      - 'src/osx/**'
+      - '*.md'
+      - '*.yml'
+  pull_request:
+    branches:
+      - master
+    paths-ignore:
+      - '.github/workflows/ci.yml'
+      - '.github/workflows/ci_cmake.yml'
+      - '.github/workflows/ci_mac_selfhosted.yml'
+      - '.github/workflows/ci_msw_cross.yml'
+      - 'build/tools/appveyor*.bat'
+      - 'distrib/**'
+      - 'docs/**'
+      - 'interface/**'
+      - 'include/wx/gtk/**'
+      - 'include/wx/osx/**'
+      - 'locale/**'
+      - 'src/gtk/**'
+      - 'src/osx/**'
+      - '*.md'
+      - '*.yml'
+
+jobs:
+  msw-vs2019:
+    runs-on: windows-2019
+    name: wxMSW ${{ matrix.configuration }}/${{ matrix.platform }} MSVS 2019
+    strategy:
+      fail-fast: false
+      matrix:
+        include:
+          - configuration: 'Debug'
+            platform: 'Win32'
+          - configuration: '"DLL Release"'
+            platform: 'x64'
+
+    steps:
+      - name: Checkout
+        uses: actions/checkout@v2
+        with:
+          submodules: 'recursive'
+
+      - name: Add MSBuild to PATH
+        uses: microsoft/setup-msbuild@v1.0.2
+
+      - name: Build
+        run: |
+            msbuild /noLogo /m /p:Configuration=${{ matrix.configuration }} /p:Platform=${{ matrix.platform }} build\msw\wx_vc16.sln
+
+      - name: Build minimal sample
+        run: |
+            msbuild /noLogo /m /p:Configuration=${{ matrix.configuration }} /p:Platform=${{ matrix.platform }} samples\minimal\minimal_vc16.sln
+
+      - name: Build tests
+        run: |
+            msbuild /noLogo /m /p:Configuration=${{ matrix.configuration }} /p:Platform=${{ matrix.platform }} tests\test_vc16.sln
+
+      - name: Run tests
+        working-directory: tests
+        run: |
+            .\vc*msw*\test.exe
+
+      - name: Build GUI tests
+        run: |
+            msbuild /noLogo /m /p:Configuration=${{ matrix.configuration }} /p:Platform=${{ matrix.platform }} tests\test_gui_vc16.sln
+
+      - name: Run GUI tests
+        working-directory: tests
+        run: |
+            .\vc*msw*\test_gui.exe
diff --git a/.github/workflows/ci_msw_cross.yml b/.github/workflows/ci_msw_cross.yml
index ed8e9fb824..993d8f7696 100644
--- a/.github/workflows/ci_msw_cross.yml
+++ b/.github/workflows/ci_msw_cross.yml
@@ -9,6 +9,7 @@ on:
       - '.github/workflows/ci.yml'
       - '.github/workflows/ci_cmake.yml'
       - '.github/workflows/ci_mac_selfhosted.yml'
+      - '.github/workflows/ci_msw.yml'
       - 'build/tools/appveyor*.bat'
       - 'distrib/**'
       - 'docs/**'
@@ -29,6 +30,7 @@ on:
       - '.github/workflows/ci.yml'
       - '.github/workflows/ci_cmake.yml'
       - '.github/workflows/ci_mac_selfhosted.yml'
+      - '.github/workflows/ci_msw.yml'
       - 'build/tools/appveyor*.bat'
       - 'distrib/**'
       - 'docs/**'